Streptococcus gordonii SK12 mutant fimbriae의 면역화학적 연구
Immunochemical and functional studies of Streptococcus gordonll SK12 mutans fimbriae
윤정원, 백대일,
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윤정원 ( Yoon Jeong-Weon ) - 수원대학교 자연과학대학 유전공학과
백대일 ( Paik Dai-Il ) - 서울대학교 치과대학 예방치학교실 및 국민구강보건연구소
KMID : 0355420030270040603
Abstract
A number of adhesive properties have been associated with various streptococci that colonise on teeth. Streptococcus gordonii is known to attach ability to saliva treated hydroxyapatite, an in vitro model for bacterial interactions with salivary components of the acquired pellicle. Fimbriae on Streptococcus gordonii promotes colonization of a host by mediating bacterial adsorption to specific host tissue receptors.
1. Streptococcus gordonii SK12´ s SHA adsorption was induced by fimbriae type 1 and type 2. Mutants by the absence of two type fimbriae were lower by 20% in SHA adsorption.
2. Streptococcus gordonii SK12´ s fimbriae´ s precipitation was started in 2-4 ug Ig M of anti-Actinomyces viscosus T14V.
3. According to bactericidal assay by PMNs to Streptococcus gordonii SK12 compared with parent strain, M6 mutation was lower by 67% in bactericidal activity; and sialidase treated became 50% lower than untreated.
4. By the crossed immunoelectrophoresis of displayed variation of 32 and 43 kD of glycoprotein on fimbriae of Mutants.
키워드
당단백;Streptococcus gordonii;fimbriae;PMN;glycoprotein
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